Literature

Most of the work on 2-IB is published in peer reviewed journals:

  • Nijboer CH, Groenendaal F, Kavelaars A, Hagberg HH, van Bel F, Heijnen CJ.Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway. J Cereb Blood Flow Metab. 2007 Feb;27(2):282-92.

  • Nijboer CH, Kavelaars A, van Bel F, Heijnen CJ, Groenendaal F. Gender-dependent pathways of hypoxiaischemia- induced cell death and neuroprotection in the immature P3 rat. Dev Neurosci 2007;29(4-5):385-92.

  • Peeters-Scholte C, Koster J, Van den Tweel E, Blomgren K, Hamers N. Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxiaischemia. Dev Neurosci 2002;24:396-404.

  • Peeters-Scholte C, Koster J, Veldhuis W, Van den Tweel E, Zhu C et al. Neuroprotection by selective NOS inhibition at 24h after perinatal hypoxia-ischemia. Stroke 2002;33:2304-2310.

  • Peeters-Scholte C. Van den Tweel E, Ioroi T, Post I, Braun K et al. Pharmacological interventions in the newborn piglet in the first 24h after hypoxia ischemia. Exp Brain Res 2002;147:200-208.

  • Sup SJ, Gordon Green B, Grant SK. 2-Iminobiotin is an inhibitor of nitric oxide synthases. BBRC 1994:204:962-8.

  • Van den Tweel ER, van Bel F, Kavelaars A, Peeters-Scholte CM, Haumann J, Nijboer CH, Heijnen CJ, Groenendaal F. Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats. J Cereb Blood Flow Metab. 2005 Jan;25(1):67-74.

  • Van Dijk AJ, Jonker FH, Taverne MAM. The effect of administration of 2-iminobiotin at birth on growth rates, morbidity and mortality in piglets under farm conditions. Livestock Science 2007. DOI:10.1016. Livestock Science 2008; 115;129-136.

  • Zhu C, Wang X, Qiu L, Peeters-Scholte C, Hagberg H, Blomgren K. Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia. J Neurochem. 2004 Jul;90(2):462-71.