The results of the work on 2-IB is published in the following peer reviewed journals:

  • Laurent M. A. Favié, Cacha M. P. C. D. Peeters-Scholte, Anouk Bakker, Huibert Tjabbes, Toine C. G. Egberts, Frank van Bel, Carin M. A. Rademaker, Peter Vis and Floris Groenendaal. Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia. Pediatric Research, doi:10.1038/s41390-019-0587-1. For more information see following link. 
  • Albrecht M, Zitta K, Groenendaal F, Bel van F, Peeters-Scholte C. Neuroprotective strategies following perinatal hypoxia-ischemia: Taking aim at NOS. Albrecht et al Free Radic. Biol. Med. February 2th 2019
  • Favié L, Cox A, Hoogen van den A., Nijboer C, Peeters-Scholte C, Bel van F, Egberts T, Rademaker C, Groenendaal F. Nitric oxide synthase inhibition as a neuroprotective strategy following hypoxic-ischemic encephalopathy evidence from animal studies. Frontier in Neurology April 19th 2018

  • Zitta K, Peeters-Scholte C, Sommer L, Gruenewald M, Hummitzsch Lars, Parczany K, Steinfath M, Albrecht M. 2-Iminobiotin superimposed on hypothermia protects human neuronal cells from hypoxia-induced cell damage: An in-vitro study. Frontiers in Pharmacol 2018 (in press)

  • Zitta K, Peeters-Scholte C, Sommer L, Parczany K, Steinfath M, Albrecht M. Insights into the neuroprotective mechanisms of 2-iminobiotin employing an in-vitro model of hypoxic-ischemic cell injury. Eur J Pharmacol. 2016 Dec 5;792:63-69.

  • Bjorkman ST, Ireland Z, Fan X, van der Wal WM, Roes KC, Colditz PB, Peeters-Scholte CM. Short-term dose-response characteristics of 2-iminobiotin immediately postinsult in the neonatal piglet after hypoxia-ischemia. Stroke.2013 Mar;44(3):809-11.

  • Fan X, Kavelaars A, Heijnen CJ, Groenendaal F, van Bel F. Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injury. Curr Neuropharmacol. 2010 Dec;8(4):324-34.

  • Phase 1 clinical study: First-in-man 2-IB dose escalation study

  • Fan X, van Bel F. Pharmacological neuroprotection after perinatal asphyxia. J Matern Fetal Neonatal Med. 2010 Oct;23 Suppl 3:17-9.

  • Van Dijk AJ, Jonker FH, Taverne MAM. The effect of administration of 2-iminobiotin at birth on growth rates, morbidity and mortality in piglets under farm conditions. Livestock Science 2007. DOI:10.1016. Livestock Science 2008; 115;129-136.

  • Nijboer CH, Kavelaars A, van Bel F, Heijnen CJ, Groenendaal F. Gender-dependent pathways of hypoxiaischemia- induced cell death and neuroprotection in the immature P3 rat. Dev Neurosci 2007;29(4-5):385-92.

  • Nijboer CH, Groenendaal F, Kavelaars A, Hagberg HH, van Bel F, Heijnen CJ. Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway. J Cereb Blood Flow Metab. 2007 Feb;27(2):282-92.

  • Van den Tweel ER, van Bel F, Kavelaars A, Peeters-Scholte CM, Haumann J, Nijboer CH, Heijnen CJ, Groenendaal F. Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats. J Cereb Blood Flow Metab. 2005 Jan;25(1):67-74.

  • Peeters-Scholte C, van den Tweel E, Groenendaal F, van Bel F. Redox state of near infrared spectroscopy-measured cytochrome aa(3) correlates with delayed cerebral energy failure following perinatal hypoxia-ischaemia in the newborn pig. Exp Brain Res. 2004 May;156(1):20-6. 

  • Zhu C, Wang X, Qiu L, Peeters-Scholte C, Hagberg H, Blomgren K. Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia. J Neurochem. 2004 Jul;90(2):462-71.

  • Peeters-Scholte C, van den Tweel E, Ioroi T, Post I, Braun K, Veldhuis W,Nicolay K, Groenendaal F, van Bel F. Pharmacological interventions in the newborn piglet in the first 24 h after hypoxia-ischemia. A hemodynamic and electrophysiological perspective. Exp Brain Res. 2002 Nov;147(2):200-8. 

  • Peeters-Scholte C, Koster J, Van den Tweel E, Blomgren K, Hamers N. Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxiaischemia. Dev Neurosci 2002;24:396-404. 

  • Peeters-Scholte C, Koster J, Veldhuis W, Van den Tweel E, Zhu C et al. Neuroprotection by selective NOS inhibition at 24h after perinatal hypoxia-ischemia. Stroke 2002;33:2304-2310.

  • Peeters-Scholte C. Van den Tweel E, Ioroi T, Post I, Braun K et al. Pharmacological interventions in the newborn piglet in the first 24h after hypoxia ischemia. Exp Brain Res 2002;147:200-208. 

    Other literature on 2-iminobiotin with regard to perinatal asphyxia:
  • Cerio FG, Lara-Celador I, Alvarez A, Hilario E. Neuroprotective therapies after perinatal hypoxic-ischemic brain injury. Brain Sci. 2013 Mar 5;3(1):191-214.

  • Buonocore G, Perrone S, Turrisi G, Kramer BW, Balduini W. New pharmacological approaches in infants with hypoxic-ischemic encephalopathy. Curr Pharm Des. 2012;18(21):3086-100.

  • Ferriero DM. Neonatal brain injury. N Engl J Med. 2004 Nov 4;351(19):1985-95.

  • Sup SJ, Gordon Green B, Grant SK. 2-Iminobiotin is an inhibitor of nitric oxide synthases. BBRC 1994:204:962-8.